MMF Bests Methotrexate for Ocular Inflammatory Diseases

Mycophenolate mofetil (MMF) is superior to methotrexate for the treatment of ocular inflammatory diseases, according to a study presented at the Association for Research in Vision and Ophthalmology 2012 Annual Meeting. The researchers found that corticosteroidsparing  (complete control of inflammation on prednisone 10 mg/day or less, sustained for at least 30 days) was achieved more rapidly with MMF than with methotrexate.

To manage uveitis and other forms of ocular inflammation, ophthalmologists have borrowed the rheumatologic paradigm of using what rheumatologists call ‘disease-modifying antirheumatic drugs‘.

Methotrexate is substantially less expensive than mycophenolate mofetil. In typical therapeutic regimens, methotrexate is taken once weekly, either orally or by subcutaneous injection, whereas mycophenolate mofetil is taken twice daily by mouth on an empty stomach.

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One thought on “MMF Bests Methotrexate for Ocular Inflammatory Diseases

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